July 14, 2016

Recent Publications

2015- 2016

Rong Li, PhD


  1. Vargas P, Maiuri P, Bretou M,  SáezP, Pierobon P, Maurin M, Chabaud M, Lankar D, Obino D, Terriac E, Raab M, Thiam HR, Brocker T, Kitchen-Goosen SM, Alberts A, Sunareni P, Xia S, Li R, Voituriez R, Piel M, Lennon-Duménil AM. Innate Control of Actin Nucleation Determines Two Distinct Migration Behaviours In Dendritic Cells. (2016) Nat Cell Bio 18:43-53
  2. Potapova TA, Unruh JR, Box AC, Bradford WD, Seidel CW, Slaughter BD, Sivagnanam S, Wu Y, Li R. Karyotyping human and mouse cells using probes from single-sorted chromosomes and open source software.(2015) 59:335-346.
  3. Li Y, Wang PS, Lucas G, Li R, Yao L. ARP2/3 complex is required for directional migration of neural stem cell-derived oligodendrocyte precursors in electric fields. (2015) Stem Cell Res Ther. 21;6:41
  4. Zhu J, Heinecke D, Mulla W, Bradford WD, Rubinstein B, Box A, Haug JS and Li R. Single-cell based quantitative assay of chromosome transmission fidelity. (2015) G3 30;5:1043-1056
  5. Chen G, Mulla WA, Kucharavy A, Tsai HJ, Rubinstein B, Conkright J, McCroskey S, Bradford WD, Weems L, Haug JS, Seidel CW, Berman J and Li R. Targeting the adaptability of heterogeneous aneuploids. (2015) Cell 160:771-784
  6. Suraneni, P, Gogelson, Ben, Rubinstein, B, Noguera, P., Volkmann, N., Hanein, D., Mogilner, A, Li, R. A mechanism of leading edge protrusion in the absence of the Arp2/3 complex. (2015) Mol Bio Cell. E14-07-1250

Deborah Andrew, PhD


  1. Loganathan R, Lee JS, Wells MB, Grevengood E, Slattery M, Andrew DJ. Ribbon regulates morphogenesis of the Drosophila embryonic salivary gland through transcriptional activation and repression. Dev Biol. 2016 Jan 1;409(1):234-50
  2. Wells, M.B. and Andrew, D.J. (2015) Salivary gland cellular architecture in the Asian malaria vector mosquito Anopheles stephensiParasites and Vectors.  In press.
  3. Cheng, Y.L. and Andrew, D.J. (2015) Extracellular Mipp1 activity confers migratory advantage to epithelial cells during collective migration. Cell Reports.  Published online November 25, 2015.
  4. Hanlon, C.D. and Andrew, D.J. (2015) Outside-in signaling – a brief review of GPCR signaling with a focus on the Drosophila GPCR family. J Cell Sci 128: 3533-3542. PMID:  26345366.
  5. Fox, R.M. and Andrew, D.J. (2015) Transcriptional regulation of secretory capacity by bZip transcription factors.  Front Biol 10: 28-51.  PMID:  25821458
  6. Loganathan, R., Cheng, Y.L. and Andrew, D.J. (2015) ­Development of the Drosophila Respiratory System.  In:  Organogenetics.  Springer.  In press.
  7. Andrew, D.J. and Yelon, D. (2015) Developmental mechanisms, patterning and organogenesisis. Curr Opin Genet Dev. Epub 2015 Jun 4.

Yun Chen, PhD


Rosenberg, A.Z., Armani, M.D., Fetsch, P.A., Xi, L., Pham, T.T., Raffeld, M., Chen, Y., O’Flaherty, N., Stussman, R., Blackler, A.R., et al. (2016). High-Throughput Microdissection for Next-Generation Sequencing. PLoS One 11, e0151775.

 

Peter Devreotes, PhD


  1. Swaney K.F., Borleis J., Iglesias P.A., and Devreotes, P.N. 2015.  Novel protein Callipygian defines the back of migrating cells. PNAS 2015 Jun 30. pii:201509098. [Epub ahead of print]
  2. Tang M, Wang M, Shi C, Iglesias PA, Devreotes PN, and Huang CH  (2014).  Evolutionarily conserved coupling of adaptive and excitable networks mediates eukaryotic chemotaxis. Nat Commun. Oct 27;5:5175. PMCID: PMC4211273 [Available on 2015/4/27)]

Andrew Ewald, PhD


  1. Teo WW, Merino V, Cho S, Korangath P, Liang X, Wu R, Neumann NM, Ewald AJ, Sukumar, S, “HOXA5, a regulator of cell fate transition, impedes tumor initiation and progression in breast cancer,” Oncogene. 2016 May 9.
  2. Cheung KJ, Ewald AJ, “A collective route to metastasis: Seeding by tumor cell clusters,” Science. 2016 Apr 8;352(6282):167-9.
  3. Huebner RJ, Neumann NM, Ewald AJ, “Mammary epithelial tubes elongate through MAPK-dependent coordination of cell migration,” 2016, Feb 2, Development.
  4. Ellison D, Mugler A, Brennan M, Lee SH, Huebner RJ, Shamir ER, Woo LA, Kim J, Amar P, Nemenman I, Ewald AJ, Levchenko A, “Cell-cell communication enhances the capacity of cell ensembles to sense shallow gradients during morphogenesis”, 2016, Jan 20, PNAS
  5. Cheung KJ, Padmanaban VP, Silvestri V, Schipper K, Cohen JD, Fairchild AN, Gorin MA, Verdone JE, Pienta KJ, Ewald AJ, “Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters,” 2016, Feb 1, PNAS.
  6. Ewald AJ, “An arresting story about basement membrane invasion,” Dev Cell. 2015 Oct 26;35(2):143-4
  7. Kim , Shewan A, Ewald AJ, Werb Z, Mostov KE, “P114RhoGEF governs cell motility and lumen formation during tubulogenesis via ROCK-myosin II pathway,” J Cell Sci. 2015 Oct 19.
  8. Shamir ER and Ewald AJ, “Adhesion in mammary development: novel roles for E-cadherin in individual and collective cell migration,” Curr Top Dev Biol. 2015;112:353-82.

Andrew Holland, PhD


  1. Lambrus BG, Uetake Y, Clutario KM, Daggubati V, Snyder M, Sluder G, Holland AJ. (2015) p53 protects against genome instability following centriole duplication failure. Journal of Cell Biology 210(1), 63-77. [ pdf ]
  2. Moyer TC, Clutario KM, Lambrus BG, Daggubati V, Holland AJ. (2015) STIL binding to Plk4 activates kinase activity to promote centriole duplication. Journal of Cell Biology. 209(6), 863-78. [ pdf ]

Pablo A. Iglesias, PhD


  1. Mohan, K., Luo, T., Robinson, D. N., Iglesias, P. (2015).  Cell shape regulation through mechanosensory feedback control.  Journal of The Royal Society Interface.  12(109).  20150512.
  2. Srivastava, V., Iglesias, P., Robinson, D. N. (2015).  Cytokinesis: Robust cell shape regulation.  Seminars in Cell & Developmental Biology.
  3. Swaney, K. F., Borleis, J., Iglesias, P., Devreotes, P. N. (2015).  Novel protein Callipygian defines the back of migrating cells.  Proceedings of the National Academy of Sciences.  112(29).  E3845–E3854.
  4. Iglesias, P., Shi, C. (2014).  Comparison of adaptation motifs: temporal, stochastic and spatial responses.  IET Systems Biology.  8(6).  268-281.

Takanari Inoue, PhD


  1. Meier EL, Razavi S, Inoue T, Goley ED. A novel membrane anchor for FtsZ is linked to cell wall hydrolysis in Caulobacter crescentus. Mol Microbiol. 2016 Jul;101(2):265-80.
  2. Kim AK, DeRose R, Ueno T, Lin B, Komatsu T, Nakamura H, Inoue T. Toward total synthesis of cell function: Reconstituting cell dynamics with synthetic biology. Sci Signal. 2016 Feb 9;9(414). Review.
  3. Phua SC, Lin YC, Inoue T. An intelligent nano-antenna: Primary cilium harnesses TRP channels to decode polymodal stimuli. Cell Calcium. 2015 Oct;58(4):415-22. Review.
  4. Miyamoto T, Rho E, Inoue T. Deconvoluting AMPK dynamics. Oncotarget. 2015 Oct 13;6(31):30431-2.
  5. Garcia-Gonzalo FR, Phua SC, Roberson EC, Garcia G 3rd, Abedin M, Schurmans S, Inoue T, Reiter JF. Phosphoinositides regulate ciliary protein trafficking to modulate hedgedog signaling. Dev Cell. 2015 Aug 24;34(4):400-9.
  6. Nguyen H-N, Yang J-M, Miyamoto T, Itoh K, Rho E, Zhang Q, Inoue T, Devreotes PN, Sesaki H, and Iijima M. 2015. Opening the conformation is a master switch for the dual localization and phosphatase activity of PTEN.  Sci Rep Jul 28;5:12600. doi: 10.1038/srep12600. PMCID: PMC4517176.
  7. Miyamoto T., Rho E, Sample V., Akano H., Magari M., Ueno T., Chen M., Tokumitsu H., Zhang J., and Inoue T.* “Compartmentalized AMPK Signaling Illuminated by Genetically Encoded Molecular Sensors and Actuators” (Accepted at Cell Reports)
  8. Lin B., Yin T., Wu Y.I., Inoue T.* and Levchenko A.* “Interplay between chemotaxis and contact inhibition of locomotion determines exploratory cell migration” (Accepted at Nature Communications)

Alex Kolodkin, PhD


  1. Sun, L.O., Brady, C.M., Cahill, H., Sakuta, Dhande, O.S., Noda, M., Huberman, A.D., Nathans, J., Kolodkin, A.L.  (2015). Functional assembly of accessary optic system circuitry critical for compensatory eye movements. Neuron. 86, 971-984 [NIHMSID 677901].

Kostas Konstantopoulos, PhD


  1. E. Mathieu, C.D. Paul, R. Stahl, G. Vanmeerbeeck, V. Reumers, C. Liu, K. Konstantopoulos*, and L. Lagae* Time-lapse lens-free imaging of cell migration in diverse physical microenvironments Lab on a Chip 2016
  2. S. Curreli, B.S. Wong, O. Latinovic, K. Konstantopoulos and N.M. Stamatos Class 3 Seaphorins Induce F-Actin Reorganization in Human Dendritic Cells: Role in Cell MigrationJ Leuk Biol 2016
  3. M. Shriver, S. Marimuthu, C.D. Paul, J. Geist, T. Seale, K Konstantopoulos, and A. Kontrogianni-Konstantopoulos Giant obscurins regulate PI3K signaling in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunit Oncotarget 2016
  4. W-C Hung, J.R. Yang, C.L. Yankaskas, B.S Wong, P-H Wu, C. Pardo-Pastor, S.A. Serra, M-J Chiang, Z. Gu, D. Wirtz, M.A. Valverde, J.T. Yang, J. Zhang, and K Konstantopoulos  Confinement-sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways  Cell Reports 2016
  5. S. Gerecht and K. Konstantopoulos Editorial overview: Biological Engineering: Engineering Systems for cancer modeling, diagnostics and therapeutics Current Opinion in Chemical Engineering 2016
  6. C.D. Paul, D.J. Shea, M.R. Mahoney, A. Chai, V. Laney, W.-C. Hung, and K. Konstantopoulos The Interplay of the Physical Microenvironment, Contact Guidance and Intracellular Signaling in Cell Decision Making FASEB J 2016
  7. C.D. Paul, W.-C. Hung, D. Wirtz and K. Konstantopoulos Engineered Models of Confined Cell Migration Annual Review of Biomedical Engineering 2016
  8. D.J. Zabranskya, C.L. Yankaskas, R.L. Cochran, H.Y. Wong, S. Croessmann, D. Chu, S.M. Kavuri, M.R. Brewer, D.M. Rosen, W.B. Dalton, A. Cimino-Mathews, K. Cravero, B. Button, K. Kyker-Snowman, J. Cidado, B. Erlanger, H. Parsons, K.M. Manto, R. Bose, J. Lauring, C.L. Arteaga, K. Konstantopoulos, B.H. Park HER2 missense mutations have distinct effects on oncogenic signaling and migration PNAS 2015
  9. He, W. Chen, P.-H. Wu, A. Jimenez, B.S. Wong, A. San, K. Konstantopoulos and D. Wirtz Local 3D matrix confinement determines division axis through cell shape Oncotarget 2015
  10. P. Wang, S.-H. Chen, W.-C. Hung, C.D. Paul, F. Zhu, P.-P. Guan, D.L. Huso, A. Kontrogianni-Konstantopoulos and K. Konstantopoulos, Fluid Shear Promotes Chondrosarcoma Cell Invasion by Activating Matrix Metalloproteinase-12 via IGF-2- and VEGF-Signaling Pathways Oncogene 2015
  11. Yu, P.-P. Guan, J.-W. Guo, Y. Wang, L.L. Cao, G.-B. Xu, K. Konstantopoulos, Z.-Y. Wang, P. Wang By Suppressing the Expression of APH-1α and APH-1β, Magnesium Ions Improve the Cognitive Decline of APP/PS1 Transgenic Mice by Inhibiting the Circuits of Amyloid β-protein FASEB J 2015
  12. Shriver, K.M. Stroka, M. Vitolo, S. Martin, D.L. Huso, K. Konstantopoulos, A. Kontrogianni-Konstantopoulos Loss of Giant Obscurins from Breast Epithelium Promotes Epithelial-to-Mesenchymal Transition, Tumorigenicity and Metastasis Oncogene 2015
  13. Shea, D. Wirtz, K.J. Stebe, K. Konstantopoulos Distinct Kinetic and Mechanical Properties Govern Mucin 16- and Podocalyxin- Mediated Tumor Cell Adhesion to E- and L-selectin in Shear Flow Oncotarget 2015
  14. P.-P. Guan, J.-J. Guo, X. Yu, Y. Wang, T. Wang, K. Konstantopoulos, J.-Y. Li, Z.-Y. Wang, P. Wang The role of Cyclooxygenase-2, Interleukin-1ß and Fibroblast Growth Factor-2 in the Activation of Matrix Metalloproteinase-1 in Sheared Chondrocytes and Articular Cartilage Scientific Reports 2015
  15. P.-P. Guan, X. Yu, J-J. Guo, Y. Wang, T. Wang, J.-Y. Li, K. Konstantopoulos, Z.-Y. Wang, P. Wang By activating matrix metalloproteinase-7, shear stress promotes chondrosarcoma cell motility, invasion and lung colonization Oncotarget 2015
  16. S.-L. Cheung, D.J. Shea, N. Nicholes, A. Date, M. Ostermeier & K. Konstantopoulos Characterization of Monobody Scaffold Interactions with Ligand via Force Spectroscopy and Steered Molecular Dynamics Scientific Reports 2015
  17. K. Konstantopoulos and T. Segura Editorial overview: Materials engineering: Advances in smart and controlled delivery of therapeutic molecules Current Opinion in Chemical Engineering 2015

Sergi Regot, PhD


1: Regot S, Hughey JJ, Bajar BT, Carrasco S, Covert MW. High-sensitivity measurements of multiple kinase activities in live single cells. Cell. 2014 Jun 19;157(7):1724-34. doi: 10.1016/j.cell.2014.04.039. PubMed PMID: 24949979; PubMed Central PMCID: PMC4097317.

Douglas Robinson, PhD


  1. Bai H, Zhu Q, Surcel A, Luo T, Ren Y, Guan B, Liu Y, Wu N, Joseph NE, Wang T-L, Zhang N, Pan D, Alpini G, Robinson DN, Anders RA. Yes-Associated Protein impacts adherens junction assembly through regulating actin cytoskeleton organization. Am. J. Physiol. – Gastrointest. Liver Phys. 2016; In press.
  2. Srivastava V, Iglesias PA, Robinson DN*. 2016. Cytokinesis: Robust cell shape regulation. Semin. Cell Dev. Biol. 2016; 53:39-44.
  3. Schiffhauer ES, Luo T, Mohan K, Srivastava V, Qian X, Griffis E, Iglesias PA, Robinson DN*. Mechanoaccumulative elements of the mammalian actin cytoskeleton. Curr. Biol. 2016; 26: 1473-1479.
  4. Kothari P, Schiffhauer E, Robinson DN. Cytokinesis from nanometers to micrometers and microseconds to minutes. In Arnaud Echard (ed.) Methods Cell Biol. 2016. Elsevier, Oxford. In press.
  5. Mackenzie ACL, Kyle DD, McGinnis LA, Lee HJ, Aidana N, Robinson DN, Evans JP. Cortical mechanics and myosin-II abnormalities associated with post-ovulatory aging:  Implications for functional defects in aged eggs. Mol. Hum. Reprod. 2016; 22(6):397-409.
  6. Christianson MS, Gerolstein AL, Lee HJ, Monseur BC, Robinson DN, Evans JP. Effects of inhibition of Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) on sperm incorporation and cortical tension in mouse eggs. Mol. Reprod. Dev. 2016; 83(3): 188-189.
  7. Kim JH, Ren Y, Ng WP, Li S, Son S, Kee Y-S, Zhang S, Zhang G, Fletcher DA, Robinson DN, Chen EH. Mechanical tension drives cell membrane fusion. Dev. Cell 2015; 561-573.
  8. Srivastava V, Robinson DN. Mechanical stress and network structure drive protein dynamics during cytokinesis. Curr. Biol. 2015; 25(5): 663-670.
  9. Surcel A, Ng W-P, West-Foyle H, Zhu Q, Ren Y, Avery L, Krenc AK, Meyers D, Rock RS, Anders RA, Freel Meyers C, Robinson DN*. Pharmacological activation of myosin II paralogs to correct cell mechanics defects. Proc. Natl. Acad. Sci. USA 2015; 112(5): 1428-1433.

Geraldine Seydoux, PhD


  1. Paix A, Folkmann A, Rasoloson D, Seydoux G. (2015) High Efficiency, Homology-Directed Genome Editing in Caenorhabditis elegans Using CRISPR/Cas9 Ribonucleoprotein Complexes. Genetics, in press

Sean Sun, PhD


  1. Collective cancer cell invasion induced by coordinated contractile stresses Angela M. Jimenez Valencia, Pei-Hsun Wu, Osman N. Yogurtcu, Pranay Rao, Josh DiGiacomo, Inês Godet, Lijuan He, Meng-Horng Lee, Daniele Gilkes, Sean X. Sun, Denis Wirtz Oncotarget; 2015
  2. Flow-Driven Cell Migration under External Electric Fields Yizeng Li, Yoichiro Mori, and Sean X. Sun Physical Review Letters; 2015
  3. The twisted tauopathies: surface interactions of helically patterned filaments seen in alzheimer’s disease and elsewhere Nash D. Rochman and Sean X. Sun Soft Matter; 2015
  4. Active Biochemical Regulation of Cell Volume and a Simple Model of Cell Tension Response Jiaxiang Tao , Sean X. Sun Biophysical Journal; 2015
  5. Volume regulation and shape bifurcation in the cell nucleus D.H. Kim, B. Li, F. Si, J. Phillips, D. Wirtz, and S.X. Sun Journal of Cell Science ; 2015
  6. Stochasticity and Spatial Interaction Govern Stem Cell Differentiation Dynamics   Smith, E. Stukalin, S. Kusuma, S. Gerecht, S. X. Sun Sci. Rep; 2015
  7. Bacterial growth and form under mechanical compression Si, B. Li, W. Margolin, S. X. Sun Sci. Rep. 5, 11367; 2015
  8. The potential and electric field in the cochlear outer hair cell membrane Harland, W. Lee, W.E. Brownell, S.X.Sun Med Biol Eng Comput , 53 (5) :405-13; 2015

Shigeki Watanabe, PhD


  1. Watanabe, S. (2015). Slow or fast? A tale of synaptic vesicle recycling. Science, 350, 46-7.

Jie Xiao, PhD


  1. Lyu Z, Coltharp C, Yang X, Xiao J. Influence of FtsZ GTPase activity and concentration on nanoscale Z‐ring structure in vivo revealed by three‐dimensional superresolution imaging. Biopolymers. 2016 Jun 1.   (pdf)
  2. Coltharp C, Buss J, Plumer TM, Xiao J. Defining the rate-limiting processes of bacterial cytokinesis. Proceedings of the National Academy of Sciences. 2016 Feb 23;113(8):E1044-53.     (pdf)
  3. Buss J, Coltharp C, Shtengel G, Yang X, Hess H, Xiao J. A multi-layered protein network stabilizes the Escherichia coli FtsZ-ring and modulates constriction dynamics. PLoS Genet. 2015 Apr 7;11(4):e1005128.   (pdf)