Andrew Holland, PhD

Assistant Professor

Biography:

Dr. Andrew J. Holland is an assistant professor of molecular biology and genetics at the Johns Hopkins University School of Medicine. He has a secondary appointment in oncology. Dr. Holland’s research focuses on the molecular mechanisms that control accurate chromosome distribution and the role of mitotic errors—those related to cell division—in human health and disease. A key objective of his research is to develop cell and animal-based models to study the role of mitotic defects in genome instability and tumorigenesis.

The Holland Lab was awarded research grants from the Leukemia Research Foundation and the W.W. Smith Charitable Trust in 2013, the year Dr. Holland joined the Johns Hopkins faculty.

Dr. Holland earned both his Ph.D. and M.Res. at the U.K.’s University of Manchester. He completed a postdoctoral fellowship at the Ludwig Institute for Cancer Research at the University of California, San Diego.

Dr. Holland has published more than 20 journal articles and delivered many invited lectures. His honors include a 2013 March of Dimes Basil O”Connor Starter Research Award and a 2006 Wellcome Trust Value in People (VIP) Award. He is a member of professional organizations that include the American Society for Cell Biology, American Association for Cancer Research, and American Association for the Advancement of Science.

Research Interests

Cell division is a fundamental process forming the basis for life itself. Each time a cell divides, it makes a complete copy of its entire genome and segregates this genome such that both daughter cells receive all the genetic information required for further growth and development. Errors in the distribution of chromosomes during mitosis lead to the production of cells with an abnormal chromosome content, which in early development lead to lethal growth defects and may later contribute to the development of cancer.

The Holland lab is interested in the molecular mechanisms that control accurate chromosome distribution and the role that mitotic errors play in human health and disease. Our work utilizes a combination of chemical biology, biochemistry, cell biology and genetically engineered mice to study pathways involved in mitosis and their effect on cell and organism physiology. A major focus of the group is to develop cell and animal-based models to study the role of cell division defects in genome instability and tumorigenesis

The Holland lab is investigating in the molecular mechanisms that control accurate chromosome distribution and the role that mitotic errors play in human health and disease.